NSAIDs and Pregnancy: new elements to prefer paracetamol

Two studies suggest an increased risk of miscarriage after nonsteroidal anti-inflammatory drugs (NSAID) use during the first trimester of pregnancy. The NSAID exposure during the first trimester of pregnancy could also be related to an increased risk in congenital anomalies (specifically cardiac defects). However, this teratogenic potential remains uncertain. In practice, a benefit/risk evaluation on a case-by-case basis should always be undertaken before prescribing NSAIDs during the first trimester of pregnancy and paracetamol should, whenever possible, be used instead.